Rachel M Squillace Selected Research

ridaforolimus

7/2013	A multicenter, first-in-pediatrics, phase 1, pharmacokinetic and pharmacodynamic study of ridaforolimus in patients with refractory solid tumors.
5/2013	Combined targeting of FGFR2 and mTOR by ponatinib and ridaforolimus results in synergistic antitumor activity in FGFR2 mutant endometrial cancer models.
8/2012	Synergistic activity of the mTOR inhibitor ridaforolimus and the antiandrogen bicalutamide in prostate cancer models.
10/2011	Antitumor activity of ridaforolimus and potential cell-cycle determinants of sensitivity in sarcoma and endometrial cancer models.
6/2011	Ridaforolimus (AP23573; MK-8669), a potent mTOR inhibitor, has broad antitumor activity and can be optimally administered using intermittent dosing regimens.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Rachel M Squillace Research Topics

Disease

6	Neoplasms (Cancer) 01/2016 - 06/2011
2	Endometrial Neoplasms (Endometrial Cancer) 05/2013 - 10/2011
2	Myotonic Dystrophy (Dystrophia Myotonica) 09/2007 - 10/2002
1	Carcinogenesis 01/2016
1	Prostatic Neoplasms (Prostate Cancer) 08/2012
1	Sarcoma (Soft Tissue Sarcoma) 10/2011
1	Angiomyolipoma 07/2009
1	Insulin Resistance 07/2009
1	Tuberous Sclerosis (Bourneville's Disease) 07/2009
1	Muscular Diseases (Myopathy) 10/2002

Drug/Important Bio-Agent (IBA)

5	ridaforolimusIBA 07/2013 - 06/2011
3	Proteins (Proteins, Gene)FDA Link 07/2009 - 10/2002
2	Antineoplastic Agents (Antineoplastics)IBA 01/2016 - 07/2013
2	Biomarkers (Surrogate Marker)IBA 10/2011 - 06/2011
1	Choline KinaseIBA 01/2016
1	EnzymesIBA 01/2016
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2016
1	Phosphorylcholine (Phosphocholine)IBA 01/2016
1	Biological ProductsIBA 07/2013
1	ponatinibIBA 05/2013
1	Drug CombinationsIBA 05/2013
1	Lactate Dehydrogenase 5IBA 02/2013
1	Adenosine Triphosphate (ATP)IBA 02/2013
1	Lactic Acid (Lactate)FDA LinkGeneric 02/2013
1	bicalutamide (Casodex)FDA LinkGeneric 08/2012
1	AndrogensIBA 08/2012
1	Androgen Antagonists (Antiandrogens)IBA 08/2012
1	Sirolimus (Rapamycin)FDA Link 10/2011
1	TOR Serine-Threonine KinasesIBA 07/2009
1	PPAR gammaIBA 07/2009
1	Mechanistic Target of Rapamycin Complex 1IBA 07/2009

Therapy/Procedure

2	Therapeutics 01/2016 - 08/2012
1	Castration 08/2012